Sterol autoxidation: from phytosterols to oxyphytosterols

From Soybean Phytosterols to Steroid Hormones

Sitostanetriol is not formed in vivo from sitosterol in the rat.

In a recent study, we observed some oxyphytosterols in the plasma of healthy human subjects. This experiment was effected in order to determine if these compounds could be formed in vivo from phytosterols. Rats were fed with a high level of phytosterols (1% of the diet) and they were compared to rats deprived of phytosterols, using triglycerides purified from phytosterols. Their plasma were ana...

Consumption Habits of Low-Fat Plant Sterol-Enriched Yoghurt Enriched with Phytosterols

Abstract—The increasing interest in plant sterol enriched foods is due to the fact that they reduce blood cholesterol concentrations without adverse side effects. In this context, enriched foods with phytosterols may be helpful in protecting population against atherosclerosis and cardiovascular diseases. The aim of the present work was to evaluate in a population of Viseu, Portugal, the consump...

Tissue autoxidation inhibitors. I. The inhibition of DOPA autoxidation by extracts from normal and neoplastic tissues.

Oxyphytosterols are present in plasma of healthy human subjects.

The oxidised derivatives of phytosterols (oxyphytosterols) were identified in plasma samples from thirteen healthy human volunteers, using MS. All the samples contained noticeable quantities of (24R)-5beta,6beta-epoxy-24-ethylcholestan-3beta-ol (beta-epoxysitostanol) and (24R)-ethylcholestan-3beta,5alpha,6beta-triol (sitostanetriol) and also trace levels of (24R)-5alpha,6alpha-epoxy-24-ethylcho...